Car T Cell Therapy Side Effects

The 133 participants in the fred hutch clinical trial believed to be the largest sample size in any published study of car t cell therapy side effects had advanced leukemias or lymphomas that had proven resistant to standard therapies.

Car t cell therapy side effects.

These include neurotoxicity which can result in headache confusion and. This syndrome is caused when the transferred t cells or other immune cells responding to the new t cells release a large amount of cytokines into the blood. This happens when car t cells begin attacking cancer and trigger an. Car t cell therapy can trigger a range of side effects many of which begin subtly but can rapidly worsen.

Again tumor lysis is a side effect showing that the car t cell treatment is working perhaps too well. Cytokines are immune substances that have many different functions in the body. When the modified t cells kill the tumor cells these then break into component parts and all the leftover gunk can be floating in your bloodstream. A potentially serious complication is cytokine release syndrome crs also known as a cytokine storm.

The most common side effects seen are. Cytokine release syndrome crs you may have heard of the cytokine storm in 2018 when many people got seriously ill during flu season. Cytokine release syndrome crs. Car t cell therapy can cause a serious side effect known as cytokine release syndrome.

Despite the therapeutic successes of car t cell therapy the intervention carries the risk of severe side effects. Neurologic events can also be experienced and can be serious in some patients. Some side effects can be severe or fatal. Because it s affecting your immune system car t can cause other changes in your body too.

Serious side effects of this release can include very high fevers and dangerously low blood pressure in the days after treatment is given. Low white blood. The possible side effects that your doctor will discuss with you include. As car t cells multiply they cause massive amounts of chemicals called cytokines to be released into the blood.

Neurologic events include encephalopathy. While the therapy can lead to long lasting remissions for some patients with very advanced cancer it can also cause neurologic side effects such as speech problems tremors delirium and seizures.